There are no trailheads. Most parties fly commercial to Kotzebue or Bettles, then charter an authorized air taxi into the park. Practical drop zones are gravel bars near the Salmon River headwaters; a common start for float trips is the Anaktok–Sheep Creek confluence, reachable by small plane from Kotzebue or the nearby village of Kiana. Another strategy is a boat-supported approach along the Kobuk River from villages like Ambler, Shungnak, or Kobuk, followed by off-trail travel to your objective. Expect entirely cross-country navigation—tundra, tussocks, alder, and river crossings.