The Chesapeake & Ohio mainline reached Thurmond in 1873, the same year Captain William Dabney Thurmond bought 73 acres beside the railroad. The location grew into a shipping and service hub for the region's coal and timber industries. In 1910, freight tonnage through Thurmond exceeded Cincinnati and Richmond combined, and 75,000 passengers passed through that year.
At its peak, the town had two hotels, two banks, restaurants, stores, a jewelry shop, a movie theater and railroad offices. With most flat ground claimed by the railroad, many residents lived in apartments above businesses. The Great Depression, fires, automobile travel and the switch from steam to diesel all helped shrink the town. Thurmond remains incorporated and former residents still gather for an annual reunion.